iPSCs are short for induced pluripotent stem cells, a type of stem cell created by reprogramming mature cells, more commonly skin or blood cells, by reverting them into a primitive, embryonic-like, pluripotent state. In this state, iPSCs can be an endless source for differentiating into any type of human cell. First generated in 2006, iPSCs are crucial for therapeutic use in the medical field.
Regarded as one of the most significant breakthroughs in recent scientific history, iPSCs were first generated by Shinya Yamanaka’s team at Kyoto University, Japan. It involves reprogramming matured cells by introducing a specific set of transcription factors, (c-Myc, Oct3/4, Sox2 and Klf4) to convert somatic cells to pluripotent stem cells.
Yamanaka then won the Nobel Prize in 2012 for the discovering that “mature, specialised cells can be reprogrammed to become immature cells capable of developing into all types of human cells.”
iPSCs, created through "reverse engineering", share the same versatile traits as the most basic stem cells. They can transform into any bodily cell, a trait formerly only possessed by embryonic stem cells.
iPSCs can be derived from an individual's own cells (autologous), making it possible to cultivate specific cell types as needed for medical purposes.
In contrast to HSCs and MSCs, iPSCs expansion is endless, opening up exciting possibilities for tissue repair therapies.
CryoCord promotes the utilisation of cord blood cells for conversion into iPSCs as they are less likely to accumulate genetic mutations when compared to adult cells.
Cord blood is collected from the umbilical cord and isolated through centrifugation. These isolated cells subsequently undergo a reprogramming process to transform into pluripotent stem cells.
CordPSCs-i are stem cells generated by reprogramming cord blood cells into a pluripotent state. CordPSCs-i are placed within multi-compartment storage before cryopreservation. This approach ensures that when the cells are required, a single vial containing pluripotent cells can be easily thawed. These cells are then cultured and induced to differentiate into the specific cell types, precisely when the need arises.
We do not want scientific jargon to be in the way of you understanding the enormous health benefits and protection that cell and gene technology can bring to you and your family. Direct your questions to us. We look forward to answering them.
