Research & Publications

Clinical studies using mesenchymal stem cells on Covid-19.

Transplantation of ACE2- mesenchymal stem cells improves the outcome of patients with COVID-19 pneumonia

Clinical remission of a critically ill COVID-19 patient treated by human umbilical cord mesenchymal stem cells

Led by our stem cell experts, the CryoCord group has been involved in over 300 stem cell-related publications over the years. Below are some of the research publications conducted by our experts and their associates.

MOK (2003) Isolation and identification of putative MSC rom BM

Choong (2007) Generating neuron-like cells from BMMSC in vitro

Choong (2007) MSC-like characteristics of corneal keratocytes

Mok (2008) In-vitro differentiation study on isolated MSC

Wong (2008) Differentiation of hMSC into mesangial cells in post-glomerular injury murine model

Mok (2009) In vitro expression of erythropoietin by transfected hMSC

Chin (2010) Cryopreserved MSC for severe dilated ischemic cardiomyopathy

Chin (2011) Intramyocardial and intracoronary MSC treatment in chronic severe DCM

Human Dental Pulp Stem Cells (DPSCs) Therapy in Rescuing Photoreceptors and Establishing a Sodium Iodate-Induced Retinal Degeneration Rat Model

Headway and The Remaining Hurdles of Mesenchymal Stem Cells Therapy for Bronchopulmonary Dysplasia

Ongoing Clinical Trials

Umbilical Cord derived Mesenchymal Stem Cell as Therapeutic Option for Refractory/ Complex Anal Fistula Associated with Crohn’s Disease

Purpose of study:
Exploring stem cells as a therapeutic option to treat perianal fistula in patients with Crohn’s disease.

Lead/ Principal Investigator:
Prof. Dr. April Camilla Roslani

Study Centre:
University of Malaya Medical Centre

Study Sponsor:
CryoCord

This study is approved by the Malaysia Ministry of Health and National Pharmaceutical Regulatory Agency.

NPRA’s Clinical Trial Exemption (CTX): CTX-220107
NMMR ID.: NMRR-21-1390-60766
(https://nmrr.gov.my/research-directory/74a1cb7d-8df0-4f50-a08f-4afc2124f79c)
Clinicaltrial.gov ID: NCT05039411
(https://www.clinicaltrials.gov/ct2/show/NCT05039411?term=CryoCord&cond=fistula+and+stem+cells&draw=2&rank=1)

Qualification Criteria:

  • Age 18 years & above
  • Diagnosed with refractory/complex perianal fistula associated with Crohn’s disease
  • Not pregnant or breastfeeding
  • Do not have active cancer or on remission of less than 5 years
  • Do not have HIV, HBV, HCV, or Treponema infection
    *additional criteria apply*

For enrolment and more information, kindly contact:

Clinical site PIC:
Prof. Dr. April Camilla Roslani (Principal Investigator)
+603-7949 2070 / +603-7949 2441 (Surgery Department Office)
+603-7949 2886 / +603-7949 2351 (Clinical Investigation Centre)

Sponsor PIC:
Dr. Vijayendran        +603-8689 8888 / +603-8689 8888               vijayendran@cryocord.com.my
Mr. Maxwell              +603-8689 8888 / +603-8689 8888               maxwell@cryocord.com.my